       Document 0340
 DOCN  M9550340
 TI    [Two cases of invasive pulmonary aspergillosis in non-immunocompromised
       hosts]
 DT    9505
 AU    Sugimura S; Yoshida K; Oba H; Hashiguchi K; Nakajima M; Moriya O;
       Okimoto N; Niki Y; Soejima R; Department of Medicine, Kawasaki Medical
       School, Japan.
 SO    Nippon Kyobu Shikkan Gakkai Zasshi. 1994 Oct;32(10):1032-7. Unique
       Identifier : AIDSLINE MED/95147370
 AB    Invasive pulmonary aspergillosis generally occurs in immunocompromised
       hosts such as patients with leukemia, and other malignancies, who are
       receiving anti-cancer chemotherapy. In this report, two
       non-immunocompromised patients who developed invasive pulmonary
       aspergillosis are presented. Case 1: A 63-year-old man complained of
       productive cough and fever. He received antibiotic therapy from his
       personal physician. This symptoms did not respond, however, and dyspnea
       developed. He was then transferred to our hospital, about one month
       after the onset. The chest X-ray showed a meniscus shadow suggesting an
       aspergilloma in the right upper lung field and an infiltrative shadow in
       the remaining right lung field. Case 2: A 78-year-old man was admitted
       because of dyspnea, productive cough and appetite loss over the previous
       three months. The chest X-ray showed a meniscus shadow in the left upper
       field, an infiltrative shadow in the left lower field and a right
       pleural effusion sign was also observed. Both cases were diagnosed as
       having aspergillosis, early in their illness, by the detection of
       aspergillus antigen in their sera and histopathological and cultural
       studies of specimens obtained by TBLB. Both improved with intravenous
       amphotericin B (30 mg/day) and intravenous ulinastatin (200000 IU/day)
       administration. On the examinations conducted during hospitalization,
       there was no evidence of any immunosuppressive diseases or
       immunoincompetent conditions such as leukemia, and other malignancies
       human immunodeficiency virus infection, diabetes or alcoholism.
 DE    Aged  Amphotericin B/ADMINISTRATION & DOSAGE  Aspergillosis/DRUG
       THERAPY/*ETIOLOGY  Case Report  Drug Therapy, Combination  English
       Abstract  Glycoproteins/ADMINISTRATION & DOSAGE  Human
       *Immunocompetence  Lung Diseases, Fungal/DRUG THERAPY/*ETIOLOGY  Male
       Middle Age  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

