       Document 0405
 DOCN  M9550405
 TI    T helper subset involvement in two high antibody responder lines of mice
       (Biozzi mice): HI (susceptible) and HII (resistant) to collagen-induced
       arthritis.
 DT    9505
 AU    De Franco M; Gille-Perramant MF; Mevel JC; Couderc J; Laboratoire
       d'Immunogenetique, Institut Curie, Paris, France.
 SO    Eur J Immunol. 1995 Jan;25(1):132-6. Unique Identifier : AIDSLINE
       MED/95145516
 AB    CD4+ T helper cells play a critical role in the chronicity of
       collagen-induced arthritis (CIA) in mice. The present results focus on
       the involvement of Th1 and Th2 subsets at the initial stage of the
       experimental disease in two lines of mice selected for high antibody
       production: HI that is susceptible, and HII that is resistant to CIA.
       Both lines are known to be H-2q, display an identical full set of V-beta
       genes, and mount similar antibody responses to both heterologous and
       autologous CII. The kinetic analysis of local T cell and anti-bovine CII
       antibody responses was followed by Elispot assays, the production of
       interferon-gamma (IFN-gamma) and IgG2a being considered indicative of a
       Th1 profile, and interleukin-5 (IL-5) as well as IgG1-IgE, of a Th2
       profile. The number of IL-5 Elispots is constantly higher in susceptible
       than in resistant mice. The IFN-gamma production is rather low in HI
       compared to HII, and besides, preferential help is observed for the
       Th2-dependent IgG1-IgE isotype-producing B cells in HI, while a
       switch-over toward IgG2a anti-CII isotype is found in HII. These results
       suggest that a Th1 preeminence at the onset of the anti-CII response is
       decisive in the resistance to CIA.
 DE    Animal  Arthritis, Adjuvant/*IMMUNOLOGY  Cells, Cultured
       Collagen/IMMUNOLOGY  Enzyme-Linked Immunosorbent Assay/METHODS
       IgE/BIOSYNTHESIS  IgG/*BIOSYNTHESIS/IMMUNOLOGY  Immunity,
       Natural/IMMUNOLOGY  Interferon Type II/BIOSYNTHESIS
       Interleukin-5/BIOSYNTHESIS  Lymphocyte Transformation/IMMUNOLOGY  Mice
       Mice, Inbred Strains  Species Specificity  Support, Non-U.S. Gov't  Th1
       Cells/*IMMUNOLOGY  Th2 Cells/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

