       Document 0425
 DOCN  M9550425
 TI    Mycobacterial infections in AIDS: an overview of epidemiology, clinical
       manifestations, therapy and prophylaxis.
 DT    9505
 AU    Moroni M; Gori A; Rusconi S; Franzetti F; Antinori S; Clinic of
       Infectious Diseases, L. Sacco Hospital, University of; Milan, Italy.
 SO    Monaldi Arch Chest Dis. 1994 Dec;49(5):432-8. Unique Identifier :
       AIDSLINE MED/95144138
 AB    One of the most frequent complications of AIDS is Mycobacterial
       infections. The incidence of tuberculosis has dramatically increased in
       all countries as a result of the HIV epidemic. Lately, it has been found
       that the natural history of new Mycobacterium tuberculosis infection is
       accelerated by HIV disease. In a wide number of cases the emergence of
       Mycobacterium tuberculosis nosocomial outbreaks of drug-sensitive and
       drug-resistant strains has been reported in HIV infected patients. The
       inadequate efforts to provide complete therapy to this kind of patient
       has caused the emergence of multidrug-resistant tuberculosis, that is
       responsible for the increased mortality rate in AIDS patients. A renewed
       interest in mycobacterial infections has also been kindled by the
       occurrence of Mycobacterium avium infections in patients with acquired
       immunodeficiency syndrome. The role of Mycobacterium avium as a pathogen
       is actually confusing and controversial for clinicians who care for AIDS
       patients. Disseminated Mycobacterium avium infections occur in a high
       population of HIV infected patients with low CD4+ cell count. Recent
       studies reported that rifabutin significantly reduced the incidence of
       Mycobacterium avium bacteremia, although, new macrolides such as
       clarithromycin and azithromycin are also effective in the treatment of
       the infection. Therefore, because of the emergence of macrolides
       resistance, the use of combination therapy is highly recommended in the
       Mycobacterium avium infection management.
 DE    AIDS-Related Opportunistic Infections/DRUG THERAPY/*EPIDEMIOLOGY  Human
       Tuberculosis/DRUG THERAPY/*EPIDEMIOLOGY  JOURNAL ARTICLE  REVIEW  REVIEW
       LITERATURE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

