       Document 0141
 DOCN  M9580141
 TI    Bacterial infections: bone and joint tuberculosis.
 DT    9506
 AU    Jellis JE; University of Zambia, School of Medicine, Lusaka.
 SO    Baillieres Clin Rheumatol. 1995 Feb;9(1):151-9. Unique Identifier :
       AIDSLINE MED/95246152
 AB    In many countries of the world, there is now a dual epidemic of
       tuberculosis and HIV disease. HIV specifically eliminates the tissue
       macrophages and CD4 lymphocytes, the very cells that provide immunity
       against tuberculosis. Tuberculosis is one of the more virulent
       opportunistic infections and it therefore appears fairly early in HIV
       disease. For the same reasons, bone and joint tuberculosis is becoming
       much more common. The disturbances of the lymphocyte count, ESR and
       antigen skin tests associated with HIV, now often make tuberculosis
       difficult to distinguish from other inflammatory lesions. The only
       change in the pattern of disease that we have so far registered is an
       increased incidence of disease affecting the lumbar spine. HIV-positive
       patients respond poorly to chemotherapy and are subject to drug
       sensitivity reactions. Major surgery is fraught with infectious
       complications and should be avoided. Once Pott's paraplegia has
       developed, the demise of the HIV-positive patient is rapid.
 DE    Human  *Tuberculosis, Osteoarticular/COMPLICATIONS/DIAGNOSIS/DRUG
       THERAPY/PATHOLOGY  Tuberculosis, Spinal/COMPLICATIONS/DIAGNOSIS/DRUG
       THERAPY/  PATHOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

