       Document 0013
 DOCN  M9590013
 TI    Risk of feline infectious peritonitis in cats naturally infected with
       feline coronavirus.
 DT    9509
 AU    Addie DD; Toth S; Murray GD; Jarrett O; Department of Veterinary
       Pathology, University of Glasgow, United; Kingdom.
 SO    Am J Vet Res. 1995 Apr;56(4):429-34. Unique Identifier : AIDSLINE
       MED/95305356
 AB    A longitudinal survey of 820 cats in 73 households was conducted over a
       period of 6 years to establish the fate of pet cats that were
       seropositive after natural exposure to feline coronavirus (FCoV). In
       particular, their risk of developing feline infectious peritonitis (FIP)
       was determined. The seropositive cats were assigned to 1 of 3 groups:
       cats from households in which FIP had recently been diagnosed; cats from
       households in which FIP had not been diagnosed, but from which kittens
       had been relocated and subsequently died of FIP; and cats from
       households in which FIP had not been diagnosed. Cats in the first group
       were not at greater risk of developing FIP than were cats in the other 2
       groups. Consequently, any household in which seropositive cats live must
       be considered a potential source of FCoV that can cause FIP. There was
       no evidence that the enhanced disease, which has been described after
       experimentally induced infection of seropositive cats, exists in nature.
       Thus, analysis of the survival of the seropositive cats over periods of
       up to 36 months indicated that their risk of developing FIP decreased
       with time, suggesting the development of immunity rather than increased
       susceptibility to disease. In addition, of 56 cats deemed to have been
       naturally reinfected because their anti-FCoV antibody titers decreased
       and subsequently increased, only 3 developed FIP.
 DE    Animal  Animal Feed  Animals, Domestic  Cats/*VIROLOGY  Feline Acquired
       Immunodeficiency Syndrome/DIAGNOSIS  Feline Infectious
       Peritonitis/*EPIDEMIOLOGY/MORTALITY/  TRANSMISSION  Follow-Up Studies
       Infectious Peritonitis Virus, Feline/*ISOLATION & PURIF  Probability
       Risk Factors  Support, Non-U.S. Gov't  Survival Rate  Time Factors
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

