       Document 0023
 DOCN  M9590023
 TI    [Relationship between HLA antigens and the HIV infection in patients
       from the state of Zulia]
 DT    9509
 AU    Hassanhi MS; Rivera SE; Fuenmayor AM; Marquez GC; Salas D; de Avila LM;
       Sanabria A; de Ruiz Z; Universidad de Zulia, Instituto Hematologico de
       Occidente,; Maracaibo, Venezuela.
 SO    Sangre (Barc). 1995 Apr;40(2):109-13. Unique Identifier : AIDSLINE
       MED/95304417
 AB    PURPOSE: Some genetic factors associated to the HLA system phenotypes
       may allegedly predispose to the development of infection in patients
       exposed to the human immunodeficiency virus (HIV). So the aim of this
       study was to assess if certain HLA antigens are positive or negative
       risk factors in the development of AIDS in Zulia State. PATIENTS AND
       METHODS: A total of 62 samples were studied, 31 from HIV seropositive
       subjects and 31 form healthy individuals. The patients were
       subclassified into four groups in accordance with Atlanta's CDC
       guidelines. Tests for histocompatibility including HLA-A-B-C, DR and DQ
       typing were performed with Terasaki's technique. VIH positivity was
       determined by ELISA and confirmed by Western Blot. The statistical
       evalub1p4n was performed with the chi 2 test for antigen frequency
       comparison, the relative risk (RR) was estimated with the Ryder and
       Svelgaard test, and the inferential analysis was made by means of
       non-parametric statistics. RESULTS: Most patients were included in CDC's
       groups II and IV, 48.4% and 29.0%, respectively. Increased B35 and DQw2
       and decreased B39 and DR2 antigens were found when comparing the HLA
       distribution in the sample and the antigenic frequency of the
       population. RR > 1 was observed in the infected patients A for A1, A3,
       A10, A11, B5, B7, B12, B14, B35, B61, CW4, DR4, DRW52 and DQW2 HLA
       antigens. A positive association between symptomatic infected patients
       and antigen B35 was present (X = 7.045). CONCLUSION: The findings
       reported here suggest that antigen B35 is a major risk factor for the
       development of AIDS.
 DE    Adolescence  Adult  Case-Control Studies  Child  English Abstract
       Female  Human  HIV Infections/EPIDEMIOLOGY/*IMMUNOLOGY  HLA
       Antigens/*BLOOD  Male  Middle Age  Risk  Risk Factors  Venezuela
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

