       Document 0129
 DOCN  M9590129
 TI    Mother-to-infant transmission of hepatitis C virus.
 DT    9509
 AU    Resti M; Azzari C; Lega L; Rossi ME; Zammarchi E; Novembre E; Vierucci
       A; Department of Pediatrics, University of Florence, Italy.
 SO    Acta Paediatr. 1995 Mar;84(3):251-5. Unique Identifier : AIDSLINE
       MED/95299275
 AB    Anti-hepatitis C virus (HCV) antibodies and HCV-RNA were measured in the
       sera of 22 anti-HCV positive, HIV-1 negative mothers and their infants.
       ELISA and RIBA II were used for anti-HCV determination. HCV-RNA was
       measured by a nested polymerase chain reaction. HCV-RNA was found in 12
       of 22 mothers. All 22 children were followed for 12 months. All were
       anti-HCV positive by the fourth month; 18 became anti-HCV negative
       between the 8th and 12th month. HCV-RNA was detected in 5 of 22 infants
       in the fourth month. They remained HCV-RNA positive. All children born
       to HCV-RNA negative mothers were HCV-RNA negative while 5 of 12 babies
       born to HCV-RNA positive mothers were infected. All five infected babies
       were born to mothers infected through transfusions or drug use. ALT
       levels in mothers seemed to have no effect on mother-to-infant
       transmission. Hence evidence for perinatal transmission of HCV from
       HCV-RNA positive mothers was demonstrated in the present study.
 DE    Adult  Age Factors  Base Sequence  Comparative Study  Enzyme-Linked
       Immunosorbent Assay  Female  Follow-Up Studies  Hepatitis
       Antibodies/*ANALYSIS  Hepatitis C/*TRANSMISSION  Hepatitis C
       Viruses/*GENETICS/*IMMUNOLOGY  Human  Immunoblotting  Infant  Infant,
       Newborn  Molecular Sequence Data  Polymerase Chain Reaction  Pregnancy
       *Pregnancy Complications, Infectious  RNA, Viral/*ANALYSIS  Time Factors
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

