       Document 0140
 DOCN  M9590140
 TI    Chronic generalized obliterative arteriopathy in cattle: a sequel to
       sheep-associated malignant catarrhal fever.
 DT    9509
 AU    O'Toole D; Li H; Roberts S; Rovnak J; DeMartini J; Cavender J; Williams
       B; Crawford T; Wyoming State Veterinary Laboratory, Laramie 82070, USA.
 SO    J Vet Diagn Invest. 1995 Jan;7(1):108-21. Unique Identifier : AIDSLINE
       MED/95298915
 AB    Malignant catarrhal fever (MCF) in cattle is generally associated with a
       short clinical course and a high case fatality rate (90-95%). The
       lesions in cattle that survive acute MCF for a prolonged period or
       appear to recover have not been documented. In a naturally occurring
       outbreak of MCF in a herd of beef cattle in Wyoming, 7 of 84 yearling
       heifers (8.3% of replacement herd) and 2 of 230 cows (0.9% of cow herd)
       developed clinical signs of pyrexia, mucopurulent discharge, bilateral
       keratitis, and weight loss following contact with ewes that had lambed
       34-62 days earlier. Six of 9 affected cattle were examined postmortem
       following clinical signs (CS) that developed 2-150 days earlier. Three
       cattle with CS for < or = 39 days had lesions of regional
       lymphadenopathy and widespread severe segmental lymphoid
       arteritis-phlebitis that were typical of acute MCF, and proliferative
       intimal lesions were present in a small proportion of arteries at days
       20 and 39 of CS. By contrast, 3 cattle that survived to 90, 105, and 150
       days after clinical onset had distinctive arterial lesions in multiple
       organs, characterized by proliferative concentric fibrointimal plaques,
       disrupted inner elastic lamina, focally atrophic tunica media, and
       vasculitis of variable severity. Immunohistochemical and ultrastructural
       examination of intimal plaques identified the predominant cellular
       component to be smooth muscle cells with a contractile phenotype. No
       viral structures were seen. Serologic studies, using a competitive
       inhibition enzyme-linked immunosorbent assay (CI-ELISA) that detects
       antibody to an epitope broadly conserved among isolates of the MCF
       virus, found that 2 chronically affected cattle were serologically
       positive between days 42 and 100 of CS, with seroconversion in 1 animal
       between days 52 and 73 of CS. Seroprevalence was 7.9% in the 76
       remaining healthy animals of the replacement heifer herd and 40% (75% in
       adult sheep and 4% in lambs) in the in-contact sheep flock 77 days after
       onset of CS in the index case. This episode suggests that, in addition
       to the common and well recognized acute form of MCF in cattle, this
       viral infection encompasses a disease spectrum that includes chronic
       disease and partial to complete clinical recovery, and in recovered
       animals chronic obliterative arteriopathy is the preeminent lesion.
 DE    Animal  Animals, Domestic  Arterial Occlusive
       Diseases/ETIOLOGY/PATHOLOGY/*VETERINARY  Arteries/*PATHOLOGY  Carotid
       Arteries/PATHOLOGY/ULTRASTRUCTURE  Cattle  *Cattle Diseases  *Deer
       Disease Outbreaks/*VETERINARY  Female  Kidney/PATHOLOGY  Male  Malignant
       Catarrh/COMPLICATIONS/*EPIDEMIOLOGY  Muscle, Smooth,
       Vascular/PATHOLOGY/ULTRASTRUCTURE  Renal Artery/PATHOLOGY  Sheep  *Sheep
       Diseases  Species Specificity  Wyoming/EPIDEMIOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

