       Document 0180
 DOCN  M9590180
 TI    Polarization of Th-cell responses: a phylogenetic consequence of
       nonspecific immune defence?
 DT    9509
 AU    Garside P; Mowat AM; Dept of Immunology, University of Glasgow, Western
       Infirmary, UK.
 SO    Immunol Today. 1995 May;16(5):220-3. Unique Identifier : AIDSLINE
       MED/95298179
 AB    CD4+ T helper (Th)-cell responses are polarized into Th1 and Th2 types.
       Here, Paul Garside and Allan McI. Mowat propose that this is an
       evolutionary consequence of the relationship between specific adaptive
       immunity, individual components of the nonspecific inflammatory response
       and different types of infection. This concept has important
       implications both for understanding protective immunity and for vaccine
       design and delivery.
 DE    Animal  CD4-Positive T-Lymphocytes/CYTOLOGY/*IMMUNOLOGY  Human
       *Immunity  Phylogeny  Support, Non-U.S. Gov't  Th1 Cells/IMMUNOLOGY  Th2
       Cells/IMMUNOLOGY  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

