       Document 0378
 DOCN  M9590378
 TI    Role of fine needle aspiration in HIV disease.
 DT    9509
 AU    Binotto E; Kelly M; Torda A; Lloyd A; Jones P; Dwyer J; Warren B; Cooke
       B; Dept. of Pathology, Prince Henry Hospital, Little Bay, NSW.
 SO    Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:111 (unnumbered
       abstract). Unique Identifier : AIDSLINE ASHM6/95291721
 AB    AIM: To review the diagnostic usefulness of fine needle aspiration (FNA)
       in HIV infected patients presenting with lymphadenopathy or other
       masses. METHOD: The case records of HIV patients having FNA between 1/93
       and 7/94 were retrospectively reviewed. Clinical history, result of FNA
       and impact of result of FNA on management were assessed. The FNA is
       performed using a 25G needle and 2ml syringe. Tissue obtained is placed
       into sterile saline, Hanks solution or fixed onto a slide at the
       bedside. Microbiological and cytological examination will be discussed.
       RESULTS: 24 FNA were performed in 21 patients (18 lymph nodes and 6
       other tissues). Evaluable material was obtained in 21/24 FNA. Diagnostic
       material was obtained in 11/21 patients. 3 patients had 2 FNA performed
       at separate sites. No discordant results were obtained. Diagnostic
       material was obtained in 10/15 febrile, as opposed to 1/6 afebrile,
       patients. Diagnostic material was obtained in 9/14 inpatients as opposed
       to 2/7 outpatients. FNA was diagnostic in 4/6 with NHL and excisional
       biopsy was not required. In 3 patients MAC was isolated. 2 patients were
       symptomatic and had confirmatory cultures/biopsies. 1 patient had AFB
       isolated and has been treated for M.TB (cultures pending). FNA isolated
       S.aureus in 3 patients with clinical disease consistent with
       staphylococcal sepsis (1/3 also had NHL which was not detected by FNA).
       Alternatively misleading information was obtained in 3/21 patients. 2
       FNA suggested lymphoma but excision biopsy revealed a reactive process
       only. 1 FNA failed to detect NHL. Moreover in 7/21 patients FNA failed
       to assist the diagnostic process. 2/7 had excisional biopsies revealing
       reactive tissue only. No complications occurred. CONCLUSIONS: FNA is a
       simple and convenient procedure. Information from FNA supported
       diagnoses in 11/21 cases. The success rate was greatest in patients who
       were febrile, hospitalised or had NHL.
 DE    AIDS-Related Opportunistic Infections/PATHOLOGY  *Biopsy, Needle
       Diagnosis, Differential  Human  HIV Infections/*PATHOLOGY  Lymph
       Nodes/PATHOLOGY  Lymphoma, AIDS-Related/PATHOLOGY  Predictive Value of
       Tests  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

