       Document 0457
 DOCN  M9590457
 TI    Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and
       gp120.
 DT    9509
 AU    Westendorp MO; Frank R; Ochsenbauer C; Stricker K; Dhein J; Walczak H;
       Debatin KM; Krammer PH; Tumorimmunology Program, German Cancer Research
       Centre,; Heidelberg.
 SO    Nature. 1995 Jun 8;375(6531):497-500. Unique Identifier : AIDSLINE
       MED/95295832
 AB    The depletion of CD4+ T cells in AIDS is correlated with high turnover
       of the human immunodeficiency virus HIV-1 and associated with apoptosis.
       The molecular mechanism of apoptosis in HIV infection, however, is
       largely unknown. T-cell apoptosis might be affected by viral proteins
       such as HIV-1 Tat and gp120 (refs 10, 11). T-cell-receptor (TCR)-induced
       apoptosis was recently shown to involve the CD95 (APO-1/Fas) receptor.
       We show here that HIV-1 Tat strongly sensitizes TCR- and
       CD4(gp120)-induced apoptosis by upregulation of CD95 ligand expression.
       Concentrations of Tat found to be effective in cultures of
       HIV-1-infected cells were also observed in sera from HIV-1-infected
       individuals. Taken together, our results indicate that HIV-1 Tat and
       gp120 accelerate CD95-mediated, activation-induced T-cell apoptosis, a
       mechanism that may contribute to CD4+ T-cell depletion in AIDS.
 DE    Antigens, CD3/IMMUNOLOGY  Antigens, Surface/*IMMUNOLOGY  *Apoptosis
       Cell Line  Cross-Linking Reagents  CD4-Positive T-Lymphocytes/IMMUNOLOGY
       CD8-Positive T-Lymphocytes/IMMUNOLOGY  Gene Products,
       tat/BLOOD/*IMMUNOLOGY  Human  HIV Envelope Protein gp120/*IMMUNOLOGY
       HIV Infections/IMMUNOLOGY/PATHOLOGY  Lymphocyte Transformation  Membrane
       Glycoproteins/GENETICS/METABOLISM  Receptors, Antigen, T-Cell/IMMUNOLOGY
       Support, Non-U.S. Gov't  T-Lymphocytes/*IMMUNOLOGY  Tumor Cells,
       Cultured  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

