       Document 0492
 DOCN  M9590492
 TI    Detection of Epstein-Barr virus DNA in tongue tissues from AIDS
       autopsies without clinical evidence of oral hairy leukoplakia.
 DT    9509
 AU    Mabruk MJ; Flint SR; Toner M; Leonard N; Sheils O; Coleman DC; Atkins
       GJ; Department of Microbiology, Moyne Institute, Trinity College,;
       Dublin, Republic of Ireland.
 SO    J Oral Pathol Med. 1995 Mar;24(3):109-12. Unique Identifier : AIDSLINE
       MED/95294882
 AB    Epstein-Barr virus (EBV) DNA was detected by in situ hybridization at 3
       sites of 30 samples taken from clinically normal lateral border of
       tongue mucosa from 15 AIDS autopsies and in none of 20 samples from 10
       controls. The first positive case showed a thin layer of parakeratosis
       correlated with positive signals for EBV in one area and an adjacent
       area without obvious parakeratosis was also positive for EBV. These
       findings were present on both sides of the tongue. The second case was
       unilaterally positive for EBV and parakeratosis was absent. The
       hybridization signals were localised to koilocyte-like cells in the
       stratum spinosum, as in oral hairy leukoplakia (OHL). These observations
       suggest that the in situ hybridization technique can detect very early
       or subclinical OHL, and supports the role of EBV in the pathogenesis of
       this lesion.
 DE    Acquired Immunodeficiency Syndrome/*MICROBIOLOGY/PATHOLOGY  Adult
       Case-Control Studies  DNA, Viral/*ANALYSIS
       Epithelium/MICROBIOLOGY/PATHOLOGY  Female  Herpesvirus 4,
       Human/*GENETICS/ISOLATION & PURIF  Human  In Situ Hybridization
       Keratosis/MICROBIOLOGY/PATHOLOGY  Leukoplakia,
       Hairy/MICROBIOLOGY/PATHOLOGY  Male  Middle Age  Support, Non-U.S. Gov't
       Tongue/*MICROBIOLOGY/PATHOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

