       Document 0515
 DOCN  M9590515
 TI    CD30-positive anaplastic large cell lymphoma in a human T-cell
       lymphotropic virus-I endemic area.
 DT    9509
 AU    Takeshita M; Ohshima K; Akamatsu M; Ohgami A; Kikuchi M; Suzumiya J;
       Uike N; Okamura T; Nakayama J; Department of Pathology, School of
       Medicine, Fukuoka University,; Japan.
 SO    Hum Pathol. 1995 Jun;26(6):614-9. Unique Identifier : AIDSLINE
       MED/95293343
 AB    Clinicopathological and cytogenetic studies were performed on specimens
       from 43 patients with CD30-positive anaplastic large cell lymphoma
       (ALCL). All patients were born and lived in a human T-cell lymphotropic
       virus (HTLV)-I endemic area. Twenty-one patients (48.8%) had serum
       anti-HTLV-I antibody suggesting the presence of adult T-cell
       leukemia/lymphoma (ATL). Seventeen of them showed a clonal integration
       of complete HTLV-I proviral DNA by the Southern blot hybridization
       method in materials obtained by biopsy. Their ages ranged from 37 to 81
       years (median, 67.0), and they frequently presented with lymphadenopathy
       (82.4%) and extranodal tumors with (76.5%) as well as with rare leukemic
       changes (5.9%). Immunohistologically the lymphoma cells in 15 ATL
       patients showed a T-cell phenotype. In only one patient (5.9%) was there
       an expression of epithelial membrane antigen (EMA) in most of the
       lymphoma cells. Cytogenetically aberration of chromosome band 5q35 was
       not found in seven patients with HTLV-I proviral DNA. The overall median
       length of survival was 11.9 months for the patients with HTLV-I proviral
       DNA, indicating a worse prognosis compared with that of the age-matched
       patients with negative anti-HTLV-I antibody (P < .01). The specimens of
       the patients with HTLV-I proviral DNA had unique clinicopathological and
       cytogenetic features. These findings suggested that T-cell ALCL with
       HTLV-I proviral DNA should be considered to represent the lymphoma type
       of ATL.
 DE    Adult  Aged  Aged, 80 and over  Antigens, CD/ANALYSIS  DNA,
       Viral/ANALYSIS  Female  Human  HTLV-BLV Antibodies/BLOOD
       *HTLV-I/IMMUNOLOGY  Lymphoma, Large-Cell,
       Ki-1/CHEMISTRY/IMMUNOLOGY/PATHOLOGY/  *VIROLOGY  Male  Middle Age
       Ploidies  Support, Non-U.S. Gov't  Survival Rate  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

