       Document 0555
 DOCN  M9590555
 TI    HIV retrotransposon activity and the immunopathogenesis of AIDS.
 DT    9509
 AU    Johnson EJ; Sizemore RC; Gottlieb AA; Dept of Microbiology and
       Immunology, Tulane University School of; Medicine, New Orleans, LA
       70112-2699, USA.
 SO    Trends Microbiol. 1995 Mar;3(3):115-7. Unique Identifier : AIDSLINE
       MED/95291653
 AB    This article presents the new hypothesis that HIV retrotransposon
       insertional mutagenesis induces genomic effects that bring about immune
       dysfunction through disruption, deletion or rearrangement of the genome
       of the host. This activity may be augmented by the action of most, if
       not all, the cofactors of HIV-induced disease.
 DE    Acquired Immunodeficiency Syndrome/*ETIOLOGY/GENETICS/*IMMUNOLOGY/
       VIROLOGY  Genome, Human  Human  HIV/*GENETICS  Models, Genetic
       Mutagenesis, Insertional/*GENETICS  Retrotransposons/*GENETICS  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

