       Document 0789
 DOCN  M9590789
 TI    Complementation of vif-defective human immunodeficiency virus type 1 by
       primate, but not nonprimate, lentivirus vif genes.
 DT    9509
 AU    Simon JH; Southerling TE; Peterson JC; Meyer BE; Malim MH; Howard Hughes
       Medical Institute, University of Pennsylvania; School of Medicine,
       Philadelphia 19104-6148, USA.
 SO    J Virol. 1995 Jul;69(7):4166-72. Unique Identifier : AIDSLINE
       MED/95287468
 AB    The productive infection of many susceptible human cells, including
       lymphocytes and macrophages derived from peripheral blood, by the
       pathogenic lentivirus human immunodeficiency virus type 1 requires
       expression of the virally encoded vif (for virion infectivity factor)
       gene. Interestingly, this gene appears to have been conserved among all
       of the lentiviruses of primates and almost all of the lentiviruses of
       nonprimates. Using T cells constitutively expressing vif genes derived
       from diverse sources and virus replication assays, we show that the vif
       gene of a second primate lentivirus, simian immunodeficiency virus from
       macaques, complements vif-defective human immunodeficiency virus type 1
       but that those of three distinct nonprimate lentiviruses do not.
       Although the molecular basis for Vif function has yet to be defined, the
       potential implications of this noted restriction of vif complementarity
       are discussed.
 DE    Animal  Cell Line  Defective Viruses/*GENETICS  *Genes, vif  Genetic
       Complementation Test  Human  HIV-1/*GENETICS  Mice  Mice, Inbred BALB C
       Support, Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.  SIV/*GENETICS
       Virus Replication  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

