       Document 0891
 DOCN  M9590891
 TI    Synthesis of pyrryl aryl sulfones targeted at the HIV-1 reverse
       transcriptase.
 DT    9509
 AU    Artico M; Silvestri R; Stefancich G; Massa S; Pagnozzi E; Musu D; Scintu
       F; Pinna E; Tinti E; La Colla P; Dipartimento di Studi Farmaceutici,
       Universita di Roma, La; Sapienza, Italy.
 SO    Arch Pharm (Weinheim). 1995 Mar;328(3):223-9. Unique Identifier :
       AIDSLINE MED/95283417
 AB    Various aryl 1-pyrryl sulfones were synthesized and tested as inhibitors
       of HIV-1. 2-Nitrophenyl-2-ethoxycarbonyl-1-pyrryl sulfone, the most
       active among test derivatives, was selected as lead compound of the aryl
       pyrryl sulfone series. The in vitro anti-HIV-1 activity and cytotoxicity
       of 41 compounds is reported. Some structure-activity relationships are
       discussed also in comparison with the known NPPS (2-nitrophenyl phenyl
       sulfone).
 DE    Cell Survival/DRUG EFFECTS  Human  HIV-1/DRUG EFFECTS/*ENZYMOLOGY
       HIV-2/DRUG EFFECTS/ENZYMOLOGY  Pyrroles/*CHEMICAL SYNTHESIS/PHARMACOLOGY
       Reverse Transcriptase/*ANTAGONISTS & INHIB  Structure-Activity
       Relationship  Sulfones/*CHEMICAL SYNTHESIS/PHARMACOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

