       Document 1080
 DOCN  M9591080
 TI    Therapy of Mycobacterium avium complex infections in beige mice with
       streptomycin encapsulated in sterically stabilized liposomes.
 DT    9509
 AU    Gangadharam PR; Ashtekar DR; Flasher DL; Duzgunes N; Department of
       Medicine, University of Illinois at Chicago,; College of Medicine 60612,
       USA.
 SO    Antimicrob Agents Chemother. 1995 Mar;39(3):725-30. Unique Identifier :
       AIDSLINE MED/95314210
 AB    Mycobacterium avium complex (MAC) causes serious opportunistic
       infections in AIDS patients. Previous studies with MAC-infected beige
       mice have indicated that weekly administration of liposome-encapsulated
       streptomycin can reduce significantly the CFU in the liver and spleen.
       We examined whether streptomycin encapsulated in recently developed
       sterically stabilized liposomes with prolonged circulation times would
       have a therapeutic effect in this animal model. Two liposome types with
       prolonged circulation
       (polyethyleneglycol-distearoylphosphatidylethanolamine
       [PEG-DSPE]-distearoylphosphatidylcholine [DSPC]-cholesterol [chol] or
       phosphatidylinositol [PI]-DSPC-chol) and conventional liposomes
       (phosphatidylglycerol [PG]-phosphatidylcholine [PC]-chol) encapsulating
       streptomycin and administered twice weekly were bactericidal to MAC
       strain 101 in the spleen when the level of infection after treatment was
       compared with the level of infection before treatment. PI-DSPC-chol and
       PG-PC-chol liposomes encapsulating streptomycin were bactericidal in the
       liver. Although PG-PC-chol or PEG-DSPE-DSPE-chol liposomes encapsulating
       streptomycin were not bactericidal in the lungs, they reduced the level
       of MAC infection by more than 3 orders of magnitude compared with the
       level of MAC infection in untreated controls.
 DE    Animal  Colony Count, Microbial  Drug Carriers  Human  Liposomes
       Liver/MICROBIOLOGY  Lung/MICROBIOLOGY  Male  Mice  Mice, Inbred C57BL
       Mycobacterium avium-intracellulare Infection/*DRUG THERAPY/
       MICROBIOLOGY  Spleen/MICROBIOLOGY  Streptomycin/ADMINISTRATION &
       DOSAGE/*THERAPEUTIC USE  Support, Non-U.S. Gov't  Support, U.S. Gov't,
       P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

