       Document 1171
 DOCN  M9591171
 TI    Circulating CD4 and CD8 T cells have little impact on host defense
       against experimental vaginal candidiasis.
 DT    9509
 AU    Fidel PL Jr; Lynch ME; Sobel JD; Division of Infectious Diseases, Wayne
       State University School of; Medicine, Detroit, Michigan 48201, USA.
 SO    Infect Immun. 1995 Jul;63(7):2403-8. Unique Identifier : AIDSLINE
       MED/95309990
 AB    The etiology of recurrent vulvovaginal candidiasis in otherwise healthy
       women of child-bearing age remains an enigma. To date, results from both
       clinical studies and a murine model of vaginal candidiasis indicate that
       Candida vaginitis can occur in the presence of Candida-specific Th1-type
       cell-mediated immunity expressed in the peripheral circulation. The
       present study was designed to determine the role of circulating CD4 and
       CD8 cells in primary and secondary vaginal infections with Candida
       albicans. Vaginal fungal burden, Candida-specific delayed-type
       hypersensitivity (DTH), and lymph node cell Th1/Th2 cytokine production
       were monitored in CD4 and/or CD8 cell-depleted mice during persistent
       primary vaginal infections and secondary vaginal infections against
       which partial protection was observed. Treatment of mice with anti-CD4
       or anti-CD8 antibodies resulted in 90% or greater depletion of the
       respective cell populations. Mice depleted of CD4 cells had
       significantly reduced Candida-specific DTH and lymph node cell Th1-type
       cytokine production during a primary vaginal infection, as well as
       reduced anamnestic DTH during a secondary vaginal infection. In
       contrast, mice depleted of CD8 cells showed only reduced gamma
       interferon production during a primary infection; no alterations in DTH
       were observed. Despite reductions in DTH and cytokine production,
       however, CD4 and/or CD8 cell depletion had no effect on vaginal C.
       albicans burden in mice after a primary or secondary vaginal
       inoculation. Taken together, these results suggest that while
       circulating CD4 and CD8 cells contribute to systemic Candida-specific
       cell-mediated immunity in vaginally infected mice, neither CD4 nor CD8
       circulating T cells appear to provide significant host defenses against
       C. albicans at the vaginal mucosa.
 DE    Animal  Candidiasis, Vulvovaginal/*IMMUNOLOGY  CD4-Positive
       T-Lymphocytes/*IMMUNOLOGY  CD8-Positive T-Lymphocytes/*IMMUNOLOGY
       Female  Mice  Mice, Inbred CBA  Receptors, Antigen, T-Cell/METABOLISM
       Receptors, Interleukin-2/METABOLISM  Th1 Cells/IMMUNOLOGY  Th2
       Cells/IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

