       Document 1201
 DOCN  M9591201
 TI    Asthma and related atopic disorders in outpatients attending an urban
       HIV clinic.
 DT    9509
 AU    Lin RY; Lazarus TS; Department of Medicine, St. Vincent's Hospital and
       Medical Center; of New York, New York, USA.
 SO    Ann Allergy Asthma Immunol. 1995 Jun;74(6):510-5. Unique Identifier :
       AIDSLINE MED/95308317
 AB    BACKGROUND: Drug hypersensitivity and pruritic cutaneous disorders are
       common in human immunodeficiency virus (HIV)-infected patients.
       Systematic cross-sectional studies, detailing the pattern of atopic
       disease, however, have not been performed in patients with HIV
       infection. OBJECTIVE: To analyze the relationships between atopic
       disease and factors relating to lifestyle, environment, gender,
       genetics, and HIV disease-associated immune cell depletion. METHODS: CD4
       cell counts and interview data were recorded in a survey of 136 adult
       patients attending a community hospital-based HIV outpatient clinic. The
       reported presence of various atopic and related conditions (including
       asthma, hay fever, otitis, sinusitis, and dermatitis) were analyzed for
       prevalence and associations with CD4 cell depletion, family atopy, and
       other factors using logistic regression. RESULTS: Seventeen percent and
       15% of patients claimed to have asthma and hay fever, respectively.
       Eleven percent claimed chronic nasal symptoms without known hay fever. A
       recent CD4 count > or = 200 cells/dL was significantly associated with
       current asthma (P = .01) and this association remained after adjusting
       for other significant factors. The mean recent log CD4 count for
       patients with current asthma was significantly higher than other
       patients (5.63 +/- .73 versus 4.92 +/- 1.38, P = .001). There was no
       association between rhinitis and CD4 cell depletion. Histories of recent
       sinusitis (24%) and ear infections (16%) were common, and were
       significantly associated with current hay fever +/- chronic nasal
       symptoms (P < .05). Chronic pruritic rashes or eczema were reported in
       29% and were more frequent in those with CD4 counts < 200/dL. Family
       histories of either asthma or hay fever were significantly associated
       with several condition including hay fever +/- chronic nasal symptoms,
       otitis, drug allergy, chronic pruritic rashes or eczema, and asthma.
       CONCLUSIONS: Although atopic disorders in the setting of HIV infection
       appear to have some clinical associations similar to that reported for
       the general population, asthma appears to have a predilection towards
       less severe CD4 cell depletion. The potential role of chronic rhinitis
       +/- family atopy as risk factors for sinusitis and otitis may be
       important because treatment of selected individuals with rhinitis may
       potentially decrease some paranasal disease-related morbidity in HIV
       infection.
 DE    Adolescence  Adult  Asthma/*COMPLICATIONS  Drug Hypersensitivity
       Eczema/COMPLICATIONS  Female  Human  Hypersensitivity,
       Immediate/*COMPLICATIONS  HIV Infections/*COMPLICATIONS/IMMUNOLOGY  Male
       Respiratory Hypersensitivity/COMPLICATIONS  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

