       Document 0141
 DOCN  M95A0141
 TI    Bacteraemia in patients presenting with fever.
 DT    9510
 AU    Petit PL; Haarlem JV; Poelman M; Haverkamp MC; Wamola IA; Department of
       Microbiology, University Hospital Leiden, The; Netherlands.
 SO    East Afr Med J. 1995 Feb;72(2):116-20. Unique Identifier : AIDSLINE
       MED/95317226
 AB    In three studies, in Ghana and Kenya, blood from 639 patients admitted
       with fever was cultured. Standard treatments were antimalarials
       (54-100%) and antibiotics (39-90%). According to the criteria in use,
       however, only 10-31% had malaria alone; of those who received
       antibiotics, 66% were diagnosed with malaria, gastrointestinal
       infections, post-operative recuperations, circulatory problems, central
       nervous system disorders or FUO, and did not need antibiotics at the
       first encounter. For those with wounds and abscesses (8%), generalised
       antibiotic treatment can also be questioned. Bacteraemia was found in 71
       (11.3%) patients; in the HIV patients, however, 5 (23%) of 22 had
       bacteraemia. This is a minimum incidence, since culture techniques were
       not optimal for the isolation of fastidious microorganisms. The most
       prevalent organisms isolated were Salmonella, Klebsiella/Enterobacter
       and S. aureus. Resistance (intrinsic and extrinsic) in the Gram-
       bacteria was high: 31-100% were resistant to amoxycillin, 0-80% to
       cotrimoxazole, 15-95% to chloramphenicol and 9-15% to gentamicin. The
       need for cultures and sensitivity tests for patients with prolonged or
       undiagnosed fever is stressed. Specific treatment should be given only
       when infections, whether malarial or bacterial, have been positively
       diagnosed.
 DE    Bacteremia/*COMPLICATIONS/DRUG THERAPY/*EPIDEMIOLOGY/MICROBIOLOGY  Drug
       Resistance, Microbial  Female  Fever/*MICROBIOLOGY  Ghana/EPIDEMIOLOGY
       Hospitals, Rural  Human  Kenya/EPIDEMIOLOGY  Male  Microbial Sensitivity
       Tests  JOURNAL ARTICLE  MULTICENTER STUDY

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

