       Document 0251
 DOCN  M95A0251
 TI    A comparison of susceptibility to five antifungal agents of yeast
       cultures from burn patients.
 DT    9510
 AU    Still JM Jr; Law EJ; Belcher KE; Spencer SA; Augusta Regional Medical
       Center, Georgia, USA.
 SO    Burns. 1995 May;21(3):167-70. Unique Identifier : AIDSLINE MED/95314742
 AB    Patients with significant degrees of immunocompromise, such as cancer,
       AIDS and large burns, who have received significant amounts of
       antibiotics, may develop infections with yeast organisms. Over a 3-year
       period, all patients with positive fungal blood cultures and most wounds
       of patients with large burns considered to be a risk of yeast infection
       were selected and tested for their susceptibility to five antifungal
       agents, amphotericin B, ketoconazole, miconazole, diflucan, and
       5-fluorocytosine. In all, 244 specimens of yeast were tested: 142
       Candida albicans, 52 Candida parapsilosis, 26 Candida tropicalis and 13
       Trichosporon beigelii. A limited number of other isolates of Candida
       (12) were also encountered. All Candida organism were sensitive to
       amphotericin B. There was wide variation in regard to the susceptibility
       to the other four agents, with C. albicans and C. tropicalis being
       largely resistant to miconazole and ketoconazole. T. beigelii was
       recovered in 13 patients. One-half of these organisms was resistant to
       amphotericin B. Awareness of variations in species and susceptibility
       are helpful in the selection of appropriate therapeutic antifungal
       agents.
 DE    Amphotericin B/PHARMACOLOGY  Antifungal Agents/*PHARMACOLOGY
       Burns/*MICROBIOLOGY  Candida/DRUG EFFECTS/ISOLATION & PURIF  Comparative
       Study  Drug Resistance, Microbial  Fluconazole/PHARMACOLOGY
       Flucytosine/PHARMACOLOGY  Human  Ketoconazole/PHARMACOLOGY
       Miconazole/PHARMACOLOGY  Microbial Sensitivity Tests  Trichosporon/DRUG
       EFFECTS/ISOLATION & PURIF  Yeasts/*DRUG EFFECTS/ISOLATION & PURIF
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

