       Document 0089
 DOCN  M95B0089
 TI    Studies on the phenotypic and functional characterization of peripheral
       blood lymphocytes from patients with early-onset periodontitis.
 DT    9511
 AU    Takahashi K; Nagai A; Satoh N; Kurihara H; Murayama Y; Department of
       Periodontology and Endodontology, Okayama; University Dental School,
       Japan.
 SO    J Periodontol. 1995 May;66(5):391-6. Unique Identifier : AIDSLINE
       MED/95348949
 AB    Juvenile and rapidly progressive periodontitis are grouped under the
       heading of patients with early-onset periodontitis (EOP). Many studies
       have investigated host risk factors in the etiology of EOP patients but
       these remain inconclusive. This study was undertaken to assess the
       possibility that an abnormality in the systemic lymphocyte subpopulation
       or function is involved in the etiology of EOP patients. Fourteen (14)
       patients with juvenile periodontitis (JP), 18 with rapidly progressive
       periodontitis (RPP), 22 with adult periodontitis (AP), and 33 with a
       healthy periodontium (HP) participated in this study. Lymphocyte subsets
       were determined by using panels of monoclonal antibodies (mAbs) and
       fluorescent flow cytometry. T cell blastogenesis was evaluated by
       [3H]-thymidine uptake. Pokeweed mitogen induced immunoglobulin G (IgG)
       and IgM synthesis were detected by sandwich enzyme-linked immunosorbent
       assay. There were wide distributions of values in all examinations among
       subjects. No significant difference could be found between the
       periodontitis patients and HP groups with the exception of a high
       CD4/CD8 ratio in all patient groups (P < 0.0001) and the depressed
       percentages of CD3 positive cells noted in the AP patient group (P <
       0.0001). These results suggest that the majority of EOP patients do not
       show significantly different lymphocyte profiles from AP patients and HP
       subjects, and that lymphocyte cell dysfunctions are not always seen,
       even in EOP patients.
 DE    Adolescence  Adult  Age Factors  Aged  Antigens, CD3/ANALYSIS  CD4-CD8
       Ratio  Female  Human  IgG/BIOSYNTHESIS  IgM/BIOSYNTHESIS
       Immunophenotyping  Lymphocyte Transformation  Male  Middle Age
       Periodontitis/*IMMUNOLOGY  Periodontosis/*IMMUNOLOGY  Risk Factors
       Statistics, Nonparametric  Support, Non-U.S. Gov't  T-Lymphocyte
       Subsets/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

