       Document 0135
 DOCN  M95B0135
 TI    Differential contribution of the FcR gamma chain to the surface
       expression of the T cell receptor among T cells localized in epithelia:
       analysis of FcR gamma-deficient mice.
 DT    9511
 AU    Park SY; Arase H; Wakizaka K; Hirayama N; Masaki S; Sato S; Ravetch JV;
       Saito T; Division of Molecular Genetics, Chiba University School of;
       Medicine, Japan.
 SO    Eur J Immunol. 1995 Jul;25(7):2107-10. Unique Identifier : AIDSLINE
       MED/95347417
 AB    The function of the Fc receptors gamma chain (FcR gamma) for the
       expression of the T cell receptor (TCR) complex and for T cell
       development, especially for T cells localized in epithelia, was
       investigated by analyzing FcR gamma-deficient mice. In wild-type mice,
       CD8 alpha alpha + beta -TCR alpha beta + T cells of intestinal
       intraepithelial lymphocytes (i-IEL) utilized CD3 zeta homodimers and
       zeta-FcR gamma heterodimers, whereas CD8 alpha alpha + beta -TCR gamma
       delta + i-IEL used zeta-FcR gamma and FcR gamma homodimers in the TCR
       complex. On the other hand, these T cells in FcR gamma-deficient mice
       contained only zeta homodimers. The surface expression of the TCR
       complex was reduced in CD8 alpha alpha + beta -i-IEL and dendritic
       epidermal T cells (DETC) in these mice, whereas the development of these
       T cells was normal. The degree of reduction appeared to depend on the
       expression level of FcR gamma. In contrast to these populations, TCR
       gamma delta + intraepithelial T cells in reproductive organs (r-IEL)
       were dramatically decreased, suggesting that the development of r-IEL is
       FcR gamma-dependent, probably due to the predominant usage of FcR gamma
       homodimers in the TCR complex. These results indicate that the FcR gamma
       chain contributes differently to the TCR expression and to the
       development of T cells localized in epithelia.
 DE    Animal  CD8-Positive T-Lymphocytes/IMMUNOLOGY  Epithelium/CYTOLOGY
       Female  Macromolecular Systems  Male  Mice  Mice, Inbred C57BL
       Receptors, Antigen, T-Cell/*METABOLISM  Receptors, Fc/*DEFICIENCY
       Support, Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.  T-Lymphocyte
       Subsets/*METABOLISM  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

