       Document 0178
 DOCN  M95B0178
 TI    Human immunodeficiency virus-type 1 replication can be increased in
       peripheral blood of seropositive patients after influenza vaccination.
 DT    9511
 AU    O'Brien WA; Grovit-Ferbas K; Namazi A; Ovcak-Derzic S; Wang HJ; Park J;
       Yeramian C; Mao SH; Zack JA; Veterans Affairs Medical Center, Department
       of Medicine, West Los; Angeles, CA, USA.
 SO    Blood. 1995 Aug 1;86(3):1082-9. Unique Identifier : AIDSLINE
       MED/95345458
 AB    Despite considerable evidence that cell activation enhances human
       immunodeficiency virus-type 1 (HIV-1) replication in vitro, there is
       very little data on the role of immune activation on in vivo HIV-1
       replication. In this study, we examined the effect of influenza
       vaccination on HIV-1 replication in the peripheral blood of 20 study
       subjects, and in 14 control subjects who did not receive influenza
       vaccination. Blood was obtained from each subject on three occasions
       during the month before vaccination and again on three occasions during
       the following month. Over the study period, there was little change in
       levels of proviral DNA in peripheral blood mononuclear cells (PBMCs).
       However, peak PBMC viral RNA levels after influenza vaccination were
       significantly increased over the mean of prevaccination values. This
       change was not observed to the same extent in unvaccinated controls.
       Therefore, this is the first report showing that HIV-1 replication can
       increase in temporal association with influenza vaccination. Our results
       suggest that continued immunologic (antigenic) stimulation may result in
       increased virus load in vivo. To address the appropriateness of
       influenza vaccination in HIV-infected patients, expanded studies will be
       required to examine specific and generalized immune responses to
       vaccination, and differences in patient response based on disease stage.
 DE    Adult  CD4 Lymphocyte Count  Human  HIV Infections/*IMMUNOLOGY
       HIV-1/*GROWTH & DEVELOPMENT  Influenza Vaccine/*IMMUNOLOGY  Leukocytes,
       Mononuclear/MICROBIOLOGY  Middle Age  Polymerase Chain Reaction  RNA,
       Viral/BLOOD  Support, Non-U.S. Gov't  Support, U.S. Gov't, Non-P.H.S.
       Support, U.S. Gov't, P.H.S.  Time Factors  Vaccination/*ADVERSE EFFECTS
       *Virus Replication  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

