       Document 0189
 DOCN  M95B0189
 TI    The natural history of progressive multifocal leukoencephalopathy in
       patients with AIDS. Canadian PML Study Group.
 DT    9511
 AU    Fong IW; Toma E; St. Michael's Hospital, University of Toronto, Ontario,
       Canada.
 SO    Clin Infect Dis. 1995 May;20(5):1305-10. Unique Identifier : AIDSLINE
       MED/95345302
 AB    Progressive multifocal leukoencephalopathy (PML) is usually a fatal
       neurological disease. The natural history of PML in patients with human
       immunodeficiency virus infection was analyzed. The correlations between
       CD4+ lymphocyte count, previous diagnosis of AIDS, treatment with
       cytarabine, and survival time are reported for 28 individuals for whom
       the diagnosis of PML was confirmed by histopathologic examination. For
       16 patients (57%), PML was the AIDS-defining illness. For these 16
       patients, the mean (+/- SD) survival time after presentation was 7.5 +/-
       7.6 months (range, 1-31 months), whereas that for the 12 patients (43%)
       for whom AIDS was previously diagnosed was 3.2 +/- 2.8 months (range,
       1-11 months) (P = .01). The overall mean (+/- SD) CD4+ cell count was 85
       +/- 82/mm3 (range, 12-349/mm3). The mean (+/- SD) survival time for
       patients with CD4+ cell counts of > or = 90/mm3 at the time of
       presentation was 9.4 +/- 8.7 months, while that for patients with CD4+
       cell counts of < 90/mm3 at the time of presentation was 3.6 +/- 1.8
       months (P = .03). The nine patients did not benefit from treatment with
       cytarabine.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS/DRUG THERAPY  Adult
       Aged  Cytarabine/THERAPEUTIC USE  CD4 Lymphocyte Count  Female  Human
       Leukoencephalopathy, Progressive Multifocal/*COMPLICATIONS/DRUG  THERAPY
       Male  Middle Age  Zidovudine/THERAPEUTIC USE  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

