       Document 0213
 DOCN  M95B0213
 TI    Epidemic HIV-related Kaposi's sarcoma: a retrospective analysis and
       validation of TIS staging. GICAT. Gruppo Italiano Collaborativo AIDS e
       Tumori.
 DT    9511
 AU    Tambussi G; Repetto L; Torri V; Saracco A; Moresco L; Antinori A;
       Zerboni R; Lazzarin A; Department of Infectious Diseases, Mario Negri
       Institute, Milan,; Italy.
 SO    Ann Oncol. 1995 Apr;6(4):383-7. Unique Identifier : AIDSLINE
       MED/95345020
 AB    BACKGROUND: We wished to assess the clinical value in terms of treatment
       choice and establishment of the prognosis of the ACTG classification
       modified (TNM-TIS) according to the recent guidelines of CDC for the
       classification of the HIV infection in patients with HIV-related
       epidemic Kaposi's sarcoma (EKS). PATIENTS: We retrospectively studied
       296 HIV-positive individuals with EKS. Patients were initially
       classified according to the NYU system and then reclassified according
       to the TNM-TIS proposal which considers three major parameters: T,
       anatomical extent of the lesion; I, immune system status; S, HIV-related
       systemic illness. METHODS: Survival analyses according to patient
       characteristics and the different TNM-TIS classification stages were
       performed; curves were compared using the Kaplan-Meyer method, and
       predictive factors for survival using the Cox model. RESULTS: Of the
       parameters considered in the TNM-TIS staging system, the T variable was
       not predictive of survival. Conversely, I and S variables revealed
       predictive value in the survival analyses, when considered separately
       and together. CONCLUSIONS: The extent of cutaneous or mucosal lesions of
       Kaposi's sarcoma did not correlate with prognosis. However, both CD4+
       cell count and history of systemic illness were predictive of survival.
       Indicators of HIV infection must be included in the clinical evaluation
       of EKS patients and taken into account when choosing optimal treatment.
 DE    Acquired Immunodeficiency Syndrome/*IMMUNOLOGY/MORTALITY  Adult  Aged
       Cohort Studies  Female  Human  *Immunocompromised Host  Male  Middle Age
       Neoplasm Staging  Probability  Prognosis  Retrospective Studies
       Sarcoma, Kaposi's/*CLASSIFICATION/MORTALITY/PATHOLOGY  Survival Analysis
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

