       Document 0261
 DOCN  M95B0261
 TI    Systemic and secretory humoral immunity in the normal human vaginal
       tract.
 DT    9511
 AU    Hocini H; Barra A; Belec L; Iscaki S; Preud'homme JL; Pillot J; Bouvet
       JP; Department of Microbial Immunology, Institut Pasteur, Paris,;
       France.
 SO    Scand J Immunol. 1995 Aug;42(2):269-74. Unique Identifier : AIDSLINE
       MED/95357644
 AB    The molecular status of Abs in the vaginal fluid is reconsidered as a
       basis for immunization strategies for women' vaccination against HIV.
       Analysis of separated immunoglobulins (Igs) shows a large proportion of
       uncleaved IgG, whereas the low amount of IgA includes SIgA, monomers and
       fragments. SIgM is at a very low level, while free SC molecules are
       abundant. In addition to the already documented local synthesis, vaginal
       IgG contains serum-derived tetanus antitoxins. The IgG could reach the
       lumen by diffusion, and/or be transported by an Fc receptor-associated
       mechanism as suggested by the subclass imbalance in favour of the IgG1
       isotype. VAginal SIgA contains very low levels of antibodies o the
       cell-well carbohydrates from a dental caries-associated streptococcus
       confirming the participation of the secretory immune system. IN
       addition, the low percentage of IgA2 suggests tha a proportion of
       vaginal SIgA can also derive from actively transported serum polymers.
       In agreement with our previous studies showing induction of vaginal
       tetanus antitoxins by intramuscular immunization, these results are in
       favour of classical, parenteral vaccinations to induce protection of the
       human vagina.
 DE    Adult  Albumins/ANALYSIS  Blood Proteins/ANALYSIS  Female  Human
       Immunoglobulins/*ANALYSIS  Support, Non-U.S. Gov't  Vagina/*IMMUNOLOGY
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

